Glonoinum for Angina Pectoris – an explosive drug

Angina Pectoris – what is it?

Angina Pectoris is a symptomatology that in 2009 affected an estimate of 30 000 to 40 000 people per 1 million of the European population [1], and approximately 9.8 million people in America, with tendency rising [2].

It is a syndrome that is characterized by precordial discomfort; pressure, squeezing, burning or fullness located centrally about the chest. This is frequently accompanied by pain extending through to the back, or into the shoulder and arm, and may radiate to the throat and jaw, the upper abdomen and at times the right arm [3]. The onset of symptoms is usually due to physical exertion or stress [3], heavy meals or extreme heat [4].

The etiology of Angina Pectoris is commonly an underlying condition called myocardial ischemia [3]. Myocarial ischemia refers to a reduction of the volume of blood passing through the arteries, as a consequence of which the amount of oxygen transported to the heart is also decreased [5]. This is usually due to yet another underlying more severe issue, namely coronary heart disease, where the coronary arteries are obstructed as in the case of atherosclerosis [3]. Other causes of myocardial ischemia are spasms of the coronary arteries, or an embolism caused by the plaque formation of artheriosclerosis that then ruptures and forms a clot that blocks an artery [5].

Attacks of Angina Pectoris commonly subside after a few minutes and are relieved by rest [3]. The most important element in the treatment of Angina Pectoris is the removal of the causative factors, at least the prevention of further progression of the underlying condition [4].

First aid treatment, and the most common prescriptions in Angina Pectoris, are drugs containing nitroglycerine [4]. Nitroglycerin dilates the arteries and as such permits an increased volume of blood to flow through the vessles [4].

Nitroglycerine – an explosive drug!

In 1846 the Italian chemist Asciano Sobrero sought to create a new kind of substance that had blasting power. He synthezised Nitroglycerin by combining nitric and sulphuric acid [6, 7]. In 1867 then Alfred Nobel, the scientist and initiator of the Nobel prize, patented Nitroglycerin as a explosive [6].

The first physician to suggest nitroglycerin as a treatment for Angina Pectoris was British born William Murrell (1853 – 1912) in 1879 [7, 8]. He and few of his colleagues dared to experiment with Nitroglycerin, and trialed this explosive substance in highly diluted form on themselves. Murrell had taken Nitroglycerin 30 to 40 times before using it in the treatment of patients [8].

From experiential reports and his own findings, Murrell identified Nitroglycerin to be an instantly acting substance. The ingestion of a tiny quantity sufficed to induce a sensation of fullness about the neck, slight nausea, mental confusion and drowsiness. A rushing noise in the ears was described, a heaviness in the stomach and frequently a tensive headache that was felt over the eyes and could extend to the nose and ears [8, 9].

Murrell prescribed Nitroglycerin for patients that experienced symptoms of sudden onset of intense pain about the chest that was triggered by slightest physical exertion or emotional excitement. Patients described a sensation of heat and burning in the chest that was succeeded by an acute, painful pressue. This pain could radiate to the back, between the shoulders, and along the inner side of the arm down to the elbow. Murrell points out that this pain only rarely passed below the elbow towards or into the fingers. Shortness of breath, an increased pulsation, and a sensation of coldness in an attack were also described [8].

These attacks commonly lasted no longer than 3 to 4 minutes, and the administration of Nitroglycerin cut an attack short. Murrell exclaimed that “the action of the medicine seems to commence the moment it is swallowed” [8, p.43]. Unfortunately the ingestion of Nitroglycerin almost always produced a throbbing sensation across the forehead, at the height of the hairline, a sensation of pulsation experienced throughout the body, and a noise like running water in the ears [8]. This concomitant symptomatology of Nitroglycerin is one that for most patients still accompanies an ingestion of the drug.

Murrell further noted of Nitroglycerin that the susceptibility to its action was more pronounced in weaker individuals and women. He stressed that a physiological effect could be excited by merely handling it, and pointed out that following an administration of the drug patients would experience “an immediate, irresistible need for sleep” [8, p.29].

The homeopathic origin of nitroglycerin as a healing agent

In 1848, long before the conventional medical sphere took note of the healing potential of nitroglycerin the German Homeopath Constantin Hering (1800 – 1880) had recognized its value as a homeopathically produced remedy for throbbing and congestive headaches.

Hering never considered Glonoinum, homeopathic Nitroglycerine, for Angina Pectoris [6], but it has found its way into the homeopathic Materia Medica as a remedy for many symptoms, including those of the symptomatology of Angina Pectoris. As such it is, amongst others, indicated for the following key symptoms:

– Surging of blood to the head and heart [10, 11].

– Violent palpitation, laborious action of the heart [10, 11].

– Throbbing and pulsating headache in forehead and between temples [11].

– Throbbing in front of the head [11], that becomes worse by exertion [12].

– Pressure and throbbing in the temples [11].

– Pulsation experienced throughout the body. Pulsating pains [10], felt as if the head would burst [12].

– Paleness of the face [12].

– Adverse effects from being in the sun, sunstroke [12].

– Confusion, heaviness about the head [10].

– Can bear no heat about the head [10].

Perhaps it was due to the skepticism of the homeopathic doctrine that the conventional medical sphere took 30 years to investigate the therapeutic potential of Nitroglycerin [7], but only due to these previous investigations did Nitroglycerin at all become a successful medicinal agent. As such Nitroglycerin was considered by some as the “ first breakthrough, on a large scale, of homeopathic remedies into allopathic practice” [6, p.25]. Until today it is a reliable treatment agent for managing Angina Pectoris, both as a highly diluted conventional drug, and as a highly diluted and succussed homeopathic remedy.

References:

[1] Schillinger, W., Hasenfuss, G. (2009) Angina Pectoris. Encyclopedia of Molecular Mechanisms of Disease, pp.90-91. Available from: http://link.springer.com/referenceworkentry/10.1007%2F978-3-540-29676-8_108. [4th May 2015].

[2] Angina Pectoris (1994-2015). Available from: http://emedicine.medscape.com/article/150215-overview . [4th May 2015].

[3] Warnica, J.W. (2015) Angina Pectoris. Merck Manuals. Available from: http://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/angina-pectoris. [4th May 2015].

[4] Bhowmik, D., Das, B.C, Dutta, A.S. & Sampath Kumar, K.P. (2011) Angina Pectoris – a comprehensive review of clinical features, differential diagnosis, and remedies, Elixir Pharmacy, 40, pp.5125-5130. Available from: from elixirpublishers.com . [4th May 2015].

[5] Mayo Clinic Staff (1998-2015) Myocardial Ischemia. Mayo Clinic. Available at: http://www.mayoclinic.org/diseases-conditions/myocardial-ischemia/basics/causes/con-20035096 . [4th May 2015].

[6] Bruce Fye, W. (1986) Nitroglycerin: a homeopathic remedy Circulation, Vol. 73, 1, pp.21-29. Available from : circ.ahajournals.org/content/73/1/21.full.pdf [4th May 2015].

[7] Bruce Fye, W. (1994) William Murrell Clin. Cardiol., 18, pp. 426-427. Available from: http://onlinelibrary.wiley.com/doi/10.1002/clc.4960180714/pdf [4th May 2015].

[8] Murrell, W. (1882) Nitro-glycerine as a remedy for angina pectoris, H.K. Lewis, London.

[9] Murrell, W. (1879) Nitroglycerine as a remedy for angina pectoris. Lancet, 1:80-1, 113. Available from: http://site.hmc.org.qa/heartviews/vol8no3/PDF/HISTORYOFMEDICINE2.pdf. [4th May 2015].

[10] Boericke, W. (1999) Homeopathic Materia Medica. Available at: http://www.homeoint.org/books/boericmm/g/glon.htm . [4th May 2015].

[11] Hering, C. (2002) The guiding symptoms of our materia medica. Available at: http://www.homeoint.org/hering/g/glon-kn3.htm . [4th May 2015].

[12] Kent, J.T. (2000) Lectures on homeopathic materia medica. Available at: http://homeoint.org/books3/kentmm/glon.htm. [4th May 2015].

Iberis Amara – A homeopathic remedy for specific arrhythmia

Iberis amara is a homeopathic remedy with major characteristic symptom expressions that make it specific for particular affections of the heart. It affects the muscle of the heart, the coronary arteries, the conduction system of the heart and the peripheral circulation. As such Iberis is indicated for cardiac and coronary insufficiency, arrhythmia (tachycardia), angina pectoris, hypertrophy, myocarditis and endocarditis.

The particular heart symptomatology includes palpitation that is instigated by the slightest of physical exertion. Closing a window, coughing, laughing, or turning over in bed may suffice to produce accelerated, irregular beating of the heart. During this episode the individual may experience the sensation of dull heaviness and dragging pressure in the region of the heart, and marked shooting, darting pains that are experienced as stabbing or stitching. These symptoms promote great anxiety in the patient and may cause associated feelings of fear and nervousness. There may be marked coldness of hands and feet, while the face may be flushed with a sensation of fullness about the head and neck. Cold sweat may develop on the face. The patient desires to sigh or draw long breaths.

The heart beats faster and stronger and the actual pulsation is visible over the cardia-thoracic area. The pulse is erratic or intermittent, tremulous and not well-defined while being full and strong. The hearts action may at first be weak and is then succeeded by an increased full and strong, irregular pulse rate of +/- 100.

Concomitant to the cardiac symptoms there may be anxiety, increased salivation, dyspnea, and shortness of breath, the feeling of constriction and oppression, as well as vertigo. The patient may experience persistent eructation and bloating with an increased frequency of passing soft stool from the ingestion of food and there may be associated digestive weakness. A choking sensation may be felt in the dry throat and there may be the feeling of pressure and pain in the region of the liver. Soreness, lameness and trembling may be felt in the extremities, particular in the upper left arm and hand.

The patient feels worse for turning or lying on the left side, at night or upon rising in the morning. Altering the resting position or placing a hand on the chest above the heart does not ameliorate symptoms.

Following such an ‘attack’ there may be an increased urge to urinate only scanty quantities, and the patient may feel a general soreness and lameness throughout the body.

An interesting aspect of the therapeutic picture of Iberis amara is its association with gastro-intestinal issues. While this is not an integral part of the homeopathic remedy picture, it is so of the Materia Medica as a phyto-therapeutic agent. Iberis has been found to have antispasmodic, anti-inflammatory, anti-flatulent and calming properties, which it exerts on the mucous membranes of the digestive tract. As such it has found inclusion in herbal complex preparations aimed at treating an irritable stomach, functional dyspepsia or the colon irritable, the syndrome known as IBS, and ailments of the digestive tract associated with abdominal discomforts such as cramping and pain, motility disruption, diarrhea or obstipation. One such complex preparation is ‘Iberogast’, which in some countries is known by the name ‘STW 5’, and contains a combination of 9 different herbs. Research however has come to conclude that it is in particular the combination of the 9 herbs together that promote the efficacy of the complex. Iberis amara alone has not been found effective for the above mentioned gastro-intestinal issues.

References:

Allen, T. (1877) The Encyclopedia of pure Materia Medica . Internet Archive [Online]. Available at: https://archive.org (Accessed: April 2017).

Boericke, W. (2004) Pocket manual of homeopathic materia medica and repertory New Delhi: B.Jain publishers Ltd.

Clarke, J. (1994) A Dictionary of practical materia medica New Delhi: B.Jain publishers Ltd.

DHU (1994) Homöopathisches Repetitorium  Karlsruhe: Deutsche Homöopathie Union.

Hale, E. (1897) Materia Medica and special therapeutics of the new remedies. Internet Archive [Online]. Available at: https://archive.org (Accessed: April 2017).

Hering, C. (1879) The guiding symptoms of our Materia Medica. Internet Archive [Online]. Available at: https://archive.org (Accessed: April 2017).

Madisch, A., Holtmann, G., Plein, K. & Hotz, J. (2004) ‘Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial’, Aliment. Pharmacol. Ther., 19(), pp. 271-279 [Online]. Available at: doi:10.1111/j.1365-2036.2004.01859.x (Accessed: April 2017).

No name (1997) ‘Expertengespräch anläßlich der 51. Tagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen mit Sektion für Gastroenterologische Endoskopie’, Aerztezeitschrift für Naturheilverfahren, 38(2), pp. 146-149.

Rahimi, R. & Abdollahi, M. (2012) ‘Herbal medicines for the management of irritable bowel syndrome: A comprehensive review’, World Journal of Gastroenterology, 18(7), pp. 589-600.